منابع مشابه
No evidence for association with APOL1 kidney disease risk
27 Background: Human African trypanosomiasis (HAT) manifests as an acute form caused by 28 Trypanosoma brucei rhodesiense (Tbr) and a chronic form caused by Trypanosoma brucei 29 gambiense (Tbg). Previous studies have suggested a host genetic role in infection outcomes, 30 particularly for APOL1. We have undertaken a candidate gene association studies (CGAS) in 31 a Ugandan Tbr and a Tbg HAT en...
متن کاملAPOL1 and Cardiovascular Disease
Observational studies have long established that African Americans have a higher risk for developing chronic kidney disease (CKD) with faster progression to end-stage renal disease compared with Americans not of African descent, independent of socioeconomic and traditional clinical risk factors. But it was not until 2010 that the genetic basis behind this association became more apparent when 2...
متن کاملAPOL1 Toxin, Innate Immunity and Kidney Injury
The discovery that two common APOL1 alleles were strongly associated with nondiabetic kidney diseases in African descent populations led to hope for improved diagnosis and treatment. Unfortunately, we still do not have a clear understanding of the biological function played by APOL1 in podocytes or other kidney cells, nor how the renal risk alleles initiate the development of nephropathies. Imp...
متن کاملEffect of APOL1 disease risk variants on APOL1 gene product
Gene sequence mutations may alter mRNA transcription, transcript stability, protein translation, protein stability and protein folding. Apolipoprotein L1 (APOL1) has two sets of sequence variants that are risk factors for kidney disease development, APOL1G1 (substitution mutation) and APOL1G2 (deletion mutation). Our present study focuses on the impact of these variants on APOL1 mRNA transcript...
متن کاملObesity and Kidney Disease
The rise in the prevalence of chronic kidney disease (CKD) and an increase in the prevalence of obesity in parallel in the recent years is a great concern. CKD increases the rate of cardiovascular disease (CVD) and development of end-stage renal disease, and leads to premature death. Although no direct causality link between obesity and CKD can yet be established, this appears highly probable. ...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2021
ISSN: 0964-6906,1460-2083
DOI: 10.1093/hmg/ddab024